Pivotal Phase III Study Underscores Efficacy Of ZaviceftaTM (ceftazidime-avibactam) For Treatment Of Hospital-Acquired Pneumonia, A Leading Cause Of Mortality In Hospitals
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چکیده
NEW YORK--(BUSINESS WIRE)--Posit ive results of the REPROVE1 Study showed that patients diagnosed with hospitalacquired pneumonia (HAP), treated with Zavicefta, a novel combination antibiot ic for the treatment of certain known or suspected Gram-negative bacterial infect ions, or Meropenem (meropenem for inject ion), a broad spectrum carbapenem antibiot ic currently considered the standard of care, experienced comparable rates of clinical cure at test-of-cure 21-25 days after randomization. Clinical cure was the primary endpoint of the study and defined as a complete resolut ion of all signs and symptoms of infect ion.
منابع مشابه
Efficacy of a Ceftazidime-Avibactam combination in a murine model of Septicemia caused by Enterobacteriaceae species producing ampc or extended-spectrum β-lactamases.
Avibactam is a novel non-β-lactam β-lactamase inhibitor that has been shown in vitro to inhibit class A, class C, and some class D β-lactamases. It is currently in phase 3 of clinical development in combination with ceftazidime. In this study, the efficacy of ceftazidime-avibactam was evaluated in a murine septicemia model against five ceftazidime-susceptible (MICs of 0.06 to 0.25 μg/ml) and 15...
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متن کاملارزیابی پروفایل میکروارگانیسم های دخیل در پنومونی بیمارستانی و الگوی مقاومت آنتی بیوتیکی آن ها در بخش های مراقبت های ویژه
Background and purpose: Hospital-acquired pneumonia (HAP) is the most commonly-acquired infection in patients in intensive care units and related to a high mortality rate. Due to differences in type of microorganisms and their resistance pattern, this study was conducted to determine profile of microorganisms and their resistance pattern for initiation of more effective empirical therapy. Mate...
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